Clinical Studies Results
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*Disclaimer: Orofill Clinical Studies Results page is for professional use only. If you are our distributor or partner looking for more information, please contact us.

With over 22 targeted clinical studies and 50+ published scientific papers, our ingredients are backed by real research — not just claims.From skin to brain, from intimate comfort to daily energy, every formula we develop is designed to meet the evolving needs of women in menopause, with results you can feel and data you can trust.

Supplements Backed by Science

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100+ 
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Certified with USDA,GMP, BRC , ISO9001, 14001, 22000, HACCP, Halal and Kosher.

Evidence- based innovations to meet the evolving need
Published Scientific Papers
Years of Scientific Research

Why Our Science Matters

Multi-system focus
Skin, eyes, bones, vaginal health, brain function,
and more.

Clinically relevant
Doses studies use the same ingredients and dosages found in our products.

Real women, real results
Most trials involve women aged 40–65 — our core community.

Peer-reviewed and published
No fluff. Just research from respected journals and institutions.

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WHY IS IT SPECIAL?

Are These Changes Affecting Your Daily Life?

Skin, eyes, or mouth dryness

Hydrate from the inside out. Our oral and topical products help lock in moisture where it matters most.

Feel more at ease, every day and during intimacy — with clinically proven hydration support from within.

Vaginal dryness or discomfort

Struggling to stay sharp? Our formulas help boost mitochondrial function and mental clarity.

Brain fog or low energy

Support strong bones and mobile joints with collagen peptides and essential nutrients.

Bone or joint stiffness

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Before
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After

(Skin, Eyes, and Mouth)

Overall Dryness Studies

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Larmo et al., 2023. Journal of Nutritional Science

Khan et al., 2022. Journal of Cosmetic Dermatology

Improved Skin Hydration

A clinical study found that postmenopausal women aged 45–65 who took 500 mg of Revive daily for 12 weeks experienced a 12% increase in skin moisture and 17% improvement in elasticity compared to baseline.*

Improved Skin Repair 

  • Skin hydration increased by 31%
  • Skin elasticity increased by 22%
  • Skin mean roughness reduced by 4%

Improved Eye Hydration 

After 12 weeks of taking Revive, 90% of women reported relief from eye dryness and irritation. Clinical data showed tear secretion increased by 18%.

Vaginal Health Studies

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IMPROVED VAGINAL DYSCOMFORT

AFTER TAKING REVIVE FOR 12 WEEKS, 99% OF WOMEN EXPERIENCED NOTICEABLE IMPROVEMENT IN VAGINAL SYMPTOMS — FROM DRYNESS AND IRRITATION TO OVERALL DAILY COMFORT.

Bone & Joint Health Studies

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Supports Antioxidant Function

Yulin et al., 2021. Bone Reports

Lab data on file – Puredia 2023

Support Bone Formation

CyanthOx™ is 8 times stronger than grape seed extract (Superfoodly.com, 2019) and 1.7 times more potent french maritime pine bark extract (Legault et al., 2013).

After 3 months of using Collagen Activator, women showed a 45% increase in osteocalcin, an important bone-building protein.

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Improve vitamin D3 levels

The same participants experienced a 34% rise in 25-OH vitamin D3, a key factor for calcium absorption and bone density.

Brain Fog & Fatigue Studies

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Drapeau et al., 2019. Clinical Interventions in Aging

Liu et al., 2022. Frontiers in Pharmacology

Support Mitochondrial Activity

Support Brain Fog

BRAIN & VITALITY IS SPECIALLY FORMULATED TO ENHANCE NATURAL MITOCHONDRIAL FUNCTION, BOOSTING YOUR BRAIN'S SUSTAINED ENERGY BY 79% TO HELP YOU PERFORM AT YOUR BEST.


BRAIN & VITALITY INCREASES THREE TYPES OF REGENERATIVE STEM CELLS BY 20–33%, ENHANCING BRAIN OXYGENATION AND REPAIR TO EFFECTIVELY REDUCE SYMPTOMS OF BRAIN FOG.

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Find the Right Orofill™ Product for You

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JOIN US!

- We're building one of the most extensive research initiatives dedicated to menopausal health


- We invite clinicians, scientists, and healthcare institutions to join us in advancing evidence-based care


- Our focus: studying natural actives like sea buckthorn, collagen in real-world women


- Partner with us on human trials, observational studies, and long-term impact tracking


Help shape the future of menopause care — together